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St. Louis, MO 63141
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Bacterial Overgrowth & Medical Conditions (pdf version)
This is a study to see if budesonide foam is effective in the treatment of ulcerative proctitis. In the first half of the study everyone gets the nonabsorbed steroid foam. In the second half, patients are randomized to receiving the foam or placebo foam. All treatment costs are free. To learn more call 314-567-3377.
This is a compassionate medicine program for patients with either: severe acid reflux, gastroparesis, small intestinal pseudoobstruction, or constipation. Patients who have these conditions and have not responded to other available medicines are able to get this promotility medicine. The company pays for the medicine. The patients are responsible for the clinical follow up, blood tests and EKG tests during the years of treatment.
The purpose of this study is to determine if having too many bacteria in the small intestine is related to chronic sterile prostatitis (CP), and if treatment with a non-absorbable antibiotic called Xifaxan will help. Some people with CP also have gastrointestinal symptoms including bloating, gas, abdominal pain and change of bowel habits. Recent studies have shown that people who have these gastrointestinal symptoms frequently have small intestinal bacterial overgrowth.
You can be eligible for the CP study if a breath test that reflects bacterial overgrowth is positive.
To be eligible in this study you would need to have mild to moderately severe sterile chronic prostatitis as determined by a urologist. The symptoms must be active for at least 3 months over the last 6 months. There can be no bacterial infection in the expressed prostatic secretions or in the urine.
You would need to wait 4-6 weeks if you have had cystoscopy, infusion treatments, urethral dilatation, and antibiotics. You would need to wait for 3 months to enter the study if there has been a prostate biopsy. You would need to stop terazosin, tamsulosin, and elmiron for one month prior to starting the study.
This study would involve coming to Dr. Leonard Weinstock’s office in Creve Coeur for two visits over a period of two weeks. These visits will take 3 hours each and would include filling out questionnaires and a doing breath test. Two sets of questionnaires will be filled out at home. All participants in the study will take the antibiotic Xifaxan.
To see if you are interested in participating in the study, please read the consent form and if you wish to enroll, call Michelle at 314-400-9912.
The purpose of this study is to determine if having too many bacteria in the small intestine is related to interstitial cystitis (IC), and if treatment with a non-absorbable antibiotic called Xifaxan will help. A significant percent of people with IC also have gastrointestinal symptoms including bloating, gas, abdominal pain and change of bowel habits. Recent studies have shown that people who have these gastrointestinal symptoms frequently have small intestinal bacterial overgrowth.
You can be eligible for the IC study if a breath test that reflects bacterial overgrowth is positive.
To be eligible in this study you would need to have mild to moderately severe interstitial cystitis or painful bladder syndrome as determined by a urologist. The IC needs to be active with symptoms of bladder or pelvic pain, urinary frequency and urgency.
The major conditions that would exclude you from participating in the study include having the following: urine infection within 6 weeks, cystoscopy with Hunner’s ulcers in the bladder, bladder stone, and implanted nerve stimulator that is activated. You would need to wait 4-6 weeks if you have had cystoscopy, infusion treatments, urethral dilatation, and antibiotics. Certain medicines would need to be withdrawn before the study starts.
This study would involve coming to Dr. Leonard Weinstock’s office in Creve Coeur for three visits over a period of two weeks. Two of these visits will take 3 hours each and would include filling out questionnaires, providing a urine sample, and a doing breath test. A 2-day voiding log (recording time and volume of urine voided) will be done at home on two occasions. Two sets of questionnaires will be filled out at home. Participants in the study will take the antibiotic Xifaxan or placebo for 10 days. The chances of getting the active medicine are two to one.
To see if you would be interested in participating in the study, please read the consent form and if you are interested, please call Michelle at 314-400-9912.
The purpose of the study is to determine if having too many bacteria in the small intestine is related to Restless Legs Syndrome (RLS), and if treatment with a non-absorbable antibiotic called Xifaxan will help. A significant percent of people with RLS also have gastrointestinal symptoms including bloating, gas, abdominal pain and change of bowel habits. Recent studies have shown that people who have these gastrointestinal symptoms frequently have small intestinal bacterial overgrowth and treatment with Xifaxan helped improve both RLS and gastrointestinal symptoms.
You can be eligible for the RLS study if a breath test that reflects bacterial overgrowth is positive. To be eligible in the study you would need to have mild to moderately severe RLS. You would still be able to continue all of your current medication.
The main condition that would exclude you from participating in the study includes having the following: antibiotics or probiotics (good bacteria pills) within 6 weeks of the study.
The “placebo controlled, double blind randomized medicine” study would involve coming to Dr. Weinstock’s office located in Creve Coeur for up to two visits over a period of three weeks. The first of these visits will take 3 hours and would include filling out questionnaires, taking a blood sample, and a doing breath test. The breath test takes 3 hours and needs to be repeated after the 10 days of medicine therapy. Two sets of questionnaires will be filled out at home at day 20 and day 30.
The odds of getting the antibiotic versus placebo are 2 to 1. The costs of the office visit and the breath tests will be submitted to your insurance company and we will take what insurance will pay so that there are not additional charges to you. There is a charge by the lab for the blood tests which measure your blood count and the ferritin (iron) level (we are able to use these blood test results if they have recently been performed).
